Boosting the signal: Endothelial inward rectifier K+channels
نویسندگان
چکیده
منابع مشابه
Endothelial progenitor cells functionally express inward rectifier potassium channels.
Since the first isolation of endothelial progenitor cells (EPCs) from human peripheral blood in 1997, many researchers have conducted studies to understand the characteristics and therapeutic effects of EPCs in vascular disease models. Nevertheless, the electrophysiological properties of EPCs have yet to be clearly elucidated. The inward rectifier potassium channel (Kir) performs a major role i...
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THE HETEROGENEITY OF THE VASCULATURE in regard to regional variations in the properties of vascular smooth muscle is an area of major interest and is of primary importance in understanding circulatory regulation. The renal microcirculation represents a rather remarkable example of such heterogeneity. In cortical nephrons, the activating mechanisms of the smooth muscle myocytes comprising preglo...
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Hypercholesterolemia is an independent risk factor for development of cardiovascular disease1 and has been demonstrated to impair endothelium-dependent and independent vasodilatation.2 However, the mechanisms responsible for changes in vascular reactivity and impaired blood flow regulation induced by hypercholesterolemia remain unclear. Previous studies in cultured endothelial cells have shown ...
متن کاملATP-dependent closure and reactivation of inward rectifier K+ channels in endothelial cells.
This report presents the results of a patch-clamp study examining the role of intracellular ATP in the regulation of endothelial inward rectifier K+ channels. Administration of ATP to the cytosolic surface of inside-out patches reversibly activated the K+ channel within seconds. ATP (1 mM) increased the mean open probability by a factor of 3.5, primarily by increasing the number of openings. Ad...
متن کاملBasic fibroblast growth factor-induced endothelial proliferation and NO synthesis involves inward rectifier K+ current.
OBJECTIVE Inward rectifier K+ currents (K(ir)) determine the resting membrane potential and thereby modulate essential Ca2+-dependent pathways, like cell growth and synthesis of vasoactive agents in endothelial cells. Basic fibroblast growth factor (bFGF) acts as a vasodilatator and angiogenic factor. Therefore, we investigated the effect of bFGF on K(ir) and assessed the role in proliferation ...
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ژورنال
عنوان ژورنال: Microcirculation
سال: 2017
ISSN: 1073-9688
DOI: 10.1111/micc.12319